Cardiovascular safety of xanthine oxidase inhibitors: an optimistic and unfinished story

Gout is associated with a high risk of cardiovascular diseases and mortality. Possible causes the disease include persistent uncontrolled hyperuricemia, chronic microcrystalline inflammation that develops in vascular wall even atherosclerotic plaques. These processes, which contribute to oxidative stress formation peroxidation products, may be target for xanthine oxidase inhibitors — allopurinol febuxostat. Their rational use, aimed at complete dissolution urate crystal deposits gout patients, results improvement endothelial function, lowering blood pressure, possibly reduction all-cause The effects on safety these drugs are believed comparable, greatly expanding options therapy.